APOE Genotypes and Dementia Risk: Mechanisms and Clinical Implications

STUDIES:

Laws SM, Hone E, Gandy S, Martins RN. Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription. Journal of neurochemistry. 2003 Mar;84(6):1215-36.

Roses AD, Saunders AM. APOE is a major susceptibility gene for Alzheimer's disease. Current opinion in biotechnology. 1994 Dec 1;5(6):663-7.

Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D’Orazio LM, Buennagel DP. APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline. Nature. 2020 May 7;581(7806):71-6.

Safieh M, Korczyn AD, Michaelson DM. ApoE4: an emerging therapeutic target for Alzheimer’s disease. BMC medicine. 2019 Dec;17:1-7.

Conejero-Goldberg C, Gomar JJ, Bobes-Bascaran T, Hyde TM, Kleinman JE, Herman MM, Chen S, Davies P, Goldberg TE. APOE2 enhances neuroprotection against Alzheimer’s disease through multiple molecular mechanisms. Molecular psychiatry. 2014 Nov;19(11):1243-50.

Huang YW, Zhou B, Wernig M, Südhof TC. ApoE2, ApoE3, and ApoE4 differentially stimulate APP transcription and Aβ secretion. Cell. 2017 Jan 26;168(3):427-41.