Amyloid Beta and Ferroptosis Pathway Link in AD progression [A.I.]

This research article investigates the link between amyloid beta (Aβ), a hallmark protein associated with Alzheimer's disease (AD), and ferroptosis, a type of programmed cell death. The researchers analyzed post-mortem brain tissue from individuals with AD and found that Aβ pathology is associated with changes in the expression of proteins related to ferroptosis. They also conducted experiments with brain organoids derived from human induced pluripotent stem cells (iPSCs), demonstrating that inhibiting ferroptosis can mitigate Aβ-related effects. The study provides evidence suggesting that ferroptosis plays a crucial role in the progression of AD, and that targeting this pathway could potentially be a therapeutic strategy for preventing or slowing down the disease.

STUDY:
Majerníková, N., Marmolejo-Garza, A., Salinas, C.S. et al. The link between amyloid β and ferroptosis pathway in Alzheimer’s disease progression. Cell Death Dis 15, 782 (2024). https://doi.org/10.1038/s41419-024-07152-0